Growing Organs in a Petri Dish and Starting Labs in IIT Madras | Dr Anubama Rajan, ORGAMED Lab, IITM

Episode Summary

What comes to mind when we say organs on a dish? Before you conjure up scary images, watch this episode. Organoids or Mini Organs on a dish is a relatively new technology that deals with creating miniature versions of the human organs on a dish to enable research and testing of drugs. 

Join Amrut as he speaks to Dr. Anubama Rajan about organoids, embryogenesis, the new Department of Medical Sciences and Technology in IIT Madras, the intersection of engineering and medicine and how she feels as a woman in STEM. If you have ever been curious about the future of medicine in the current age of technology or thought about how technology can take medical science further, this episode is a must-watch.

Amrut’s Comment

Key Highlights

[00:01:57] ORGAMED lab: What does growing mini organs on a dish mean?

[00:06:59] Impact of Organoids: How do they aid in research and medical trials?

[00:12:46] Dr. Anubama’s Journey: How did she get to organoids?

[00:17:19] The Pandemic Period: How was it for a researcher of lung disease?

[00:21:24] Return to India: Why return when conditions were better in the US?

[00:24:04] Department of Medical Sciences in IIT Madras: How and why did she join the department? 

[00:29:24] The Department of Medical Sciences and Technology: The programs and the faculty

[00:36:20] Future Scope and Career Prospects: What will graduates from the department do? 

[00:41:47] SCODER lab: What does it do and how is it structured?

[00:43:46] Faculty in Social Media Era: What does it feel like?

[00:49:06] Her Personal Life: How is it to be a woman in STEM?

Institutions mentioned

[00:02:05] IIT Madras

[00:02:18] Dr. Anubama is on a panel with ISO [International Organization for Standardisation] and BIS [ Bureau of Indian Standards] for developing protocols for the creation of organoids

[00:07:34] The FDA has made calls to several labs asking for information on how to use organoids

[00:14:16] Dr. Anubama completed her graduation from Georgia State University 

[00:14:51] Dr. Anubama enrolled in the Baylor College of Medicine which she came across when she was looking for courses on virology or microbiology for her Ph.D course

[00:19:12] Institutions like the CDC [US Centers for Disease Control and Prevention] and NIH [National Institutes of Health] need to approve requests for working in Biosafety Level 3 Labs

[00:20:22] Dr. Cherry Kang is now the director of Bill & Melinda Gates Foundation 

[00:21:42] A workshop from DBT/Wellcome Trust India Alliance gave Dr. Anubama the confidence that she could return to India and continue her research

[00:24:23] Dr. Anubama mentions University of Cambridge, Harvard University, Stanford University and MIT as examples of Universities that have both engineering and medical departments

[00:35:25] Students have to do an internship at AIIMS [All India Institute of Medical Sciences] after completing their second year in the department

[00:41:49] SCoEDR is the Shankar Center of Excellence for Diabetes Research at IIT Madras

People mentioned

[00:02:21] Hans Clevers invented the technology of organoids

[00:14:58] Dr. Anthony Maresso was working on organoids at the Baylor College of Medicine 

[00:16:55] Dr. Anubama did her post doctorate work on lung organoids at Dr. Pedro A. Tony Piedra’s lab

[00:20:15] Dr. Gagandeep (Cherry) Kang was working with the Christian Medical College, Vellore 

[00:22:01] Dr. Shahid Jameel from the India Alliance Foundation speech on the changes in India’s funding ecosystem was an encouragement for Dr. Anubama

[00:24:48] Professor R Krishna Kumar is a senior professor in the Department of Medical Science and Technology and played a major role in setting up the Department

[00:25:01] Professor Boby George is the head of the Medical Science and Technology Department

[00:32:21] Professor Srikanth Vedantam is also one of the faculty at the Medical Sciences and Technology department

[00:40:16] Dr. Karthik Kailash is a spine surgeon who is also a visiting faculty at the department of Medical Sciences and Technology

[00:42:06] The SCoEDR lab is an initiative by Mr. Subramonian Shankar, an IIT Madras alumnus

[01:00:32] Dr. Pradeeba Sridhar and Dr. Rupsa Bhattacharjee write the programs and coding languages to enable a clinical result from the DMST lab data

Companies mentioned

Books & Other Media

Concepts & Models

[00:02:06] Organoid Biology is the study of miniature 3D tissue cultures called organoids, which are grown from stem cells in a laboratory setting to mimic the structure and function of organs

[00:15:46] E.Coli (Escherichia coli) is the most frequently identified bacterium in diarrheal cases across India. Different strains of E.Coli are responsible for a range of illnesses, including traveller’s diarrhoea and dysentery

[00:33:49] Cardio Mechanics refers to the study of how the heart pumps blood, involving the physical process of the heart muscle contracting and relaxing

Additional Links

Episode 14    |    61 Mins
Guest Bio

Dr. Anubama Rajan is the Principal Investigator of two labs at IIT Madras - the ORGAMED lab and the SCoEDR lab. She is also an Assistant Professor at IIT Madras. Dr. Anubama completed her Masters in Biology from Georgia State University and did her PhD in Molecular Virology and Microbiology from the Baylor College of Medicine.

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